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A new open access paper has just been published in Nature, shedding light on the detailed structure of TDP-43, a key protein implicated in neurodegenerative diseases like ALS (amyotrophic lateral sclerosis) and frontotemporal lobar degeneration (FTLD). This study provides important insights into how pathological TDP-43 filaments form, which is critical for understanding these diseases and developing potential treatments.

Access the paper here.